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The Tottenham defender scored on two occasions as Tottenham prolonged their unbeaten run on the road in the Premier League and delivered the Toffees their first defeat at Hill Dickinson Stadium.

The Toffees were unbeaten in their five previous fixtures at their new ground at the dockside location, having left their historic home behind after more than a century at the conclusion of the previous campaign.

But Tottenham's leader the Dutchman pounced on two occasions from corners in the first half to put their impressive record at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - set up by former Toffees attacker Richarlison - nodded in a third to seal the victory.

The Everton defender believed he had equalized the tally five minutes after Van de Ven's opener, glancing a powerful header past the Spurs keeper from an Everton corner.

Beto, meanwhile, missed a number of opportunities, while Vicario made a series of fine stops to ensure the London club went five matches on the road without defeat in the English top flight.

But the video assistant referee stepped in, advising Craig Pawson to review the goal on the pitchside monitor and the official decided that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.

This victory moves Thomas Frank's side into third place in the Premier League, a handful of points off local foes and leaders Arsenal.

The Merseyside club remain 14th and sit half a dozen points ahead of the drop zone.

Spurs breakdown: The defender fulfils duties at both ends of the field

After a uninspiring midweek display in the European competition against the French side, where they managed a only two shots on goal, the manager chose Randal Kolo Muani in attack instead of former Toffees player the Brazilian.

The summer signing was unable to make much of an impact before being substituted for Richarlison after 60 minutes on the pitch, but it emerged he wasn't needed in the final outcome.

Centre-back Van de Ven converted into an offensive threat to be reckoned with.

Spurs' first goal came from a cleverly executed set-piece play, with Rodrigo Bentancur directing the ball toward the face of goal for an free the defender to head home.

And the captain - stepping up as skipper in the Argentine's absence - notched his second in first-half stoppage time as he rose above Jordan Pickford to head home.

The Dutchman was just as impressive in defensive duties, partnering well with his defensive colleague as the pair dealt superbly with the 34 crosses thrown their way by Everton.

Everton analysis: Toffees lacking striker's instinct

Everton's recent stadium had been a fortress, but it seems the novelty may have worn off slightly and fans flocked to the exits after Sarr's final goal for Spurs.

The break in Everton's unbeaten home run will not be a major concern for David Moyes, but their attacking woes are.

The forward and the other striker - the Toffees' two recognised centre-forwards - had scored only one league goal between them before the weekend's outing.

And they were failed to add to that poor record on a damp and dreary evening on Merseyside.

Beto's form was summed up when he chose to bicycle-kick a golden opportunity from close range, despite having room and time to reposition for a more conventional attempt that would have challenged the keeper.

The substitute, as well, was unable to influence the game after replacing the starter in the 65th minute.

It wasn't for a lack of chance. Most of Everton's offensive moves came through the winger and Ndiaye, who tirelessly whipped threatening balls into the Tottenham penalty area.

Upcoming fixtures for these two sides?

The Toffees: The team head to Sunderland in the Premier League on early November at 20:00 GMT.

Tottenham: Spurs go to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup match against Newcastle.